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Category: Sporulation proteins

important publications

22171814,20451384,22192522,23202530,22262582,24283940,26512126

4.2.1.2. Spore coat protein/ based on similarity

Name	Function
yraD	unknown
yraE	unknown
yraF	unknown
yraG	unknown
yvdQ	protection of the spore

4.2.1.3. Small acid-soluble spore proteins

Name	Function
sspA	protection of spore DNA
sspB	protection of spore DNA
sspC	protection of spore DNA
sspD	protection of spore DNA
sspE	protection of spore DNA
sspF	protection of spore DNA
sspG	protection of spore DNA
sspH	protection of spore DNA
sspI	protection of spore DNA
sspJ	protection of spore DNA
sspK	protection of spore DNA
sspL	protection of spore DNA
sspM	protection of spore DNA
sspN	protection of spore DNA
sspO	protection of spore DNA
sspP	protection of spore DNA

4.2.1.4. Sporulation proteins/ other

Name	Function
adhB	unknown
asd	biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan
asnO	biosynthesis of asparagine
azoR2	resistance to 2-methylhydroquinone
bdbC	oxidative folding of proteins
bdbD	oxidative folding of proteins
bofA	control of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|sigma-K] activation
bofC	control of processing of pro-[protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK] by [protein\|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A\|SpoIVFB]
ccpB	unknown
cdaS	synthesis of c-di-AMP
chaA	calcium export
clpC	protein degradation, positive regulator of autolysin ([protein\|6A21293823151C6980BF52B31A4B249A8440F2E1\|LytC] and [protein\|29219315D31BA4ADE41687EFF17FE41D6C23D157\|LytD]) synthesis
coxA	resistance of the spore
csbX	unknown
csfB	control of [protein\|search\|SigG ]and [protein\|search\|SigE ]activity
ctaA	heme biosynthesis
ctpB	control of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK] activation
cwlC	mother cell lysis
cwlD	spore cortex peptidoglycan synthesis
cwlH	cell wall metabolism
dacB	control of peptide cross-linking in spore peptidoglycan
dacF	control of peptide cross-linking in spore peptidoglycan
dapA	biosynthesis of lysine and peptidoglycan
dapG	biosynthesis of lysine and peptidoglycan
divIB	septum formation
divIC	septum formation
exoA	repair of oxidative DNA damage in spores
exuR	regulation of hexuronate utilization
exuT	hexuronate uptake
fabL	fatty acid biosynthesis
fin	control of [SW\|sporulation]
fisB	release of the forespore into the mother cell cytoplasm
ftsY	protein secretion
glcU	unknown
glgA	glycogen biosynthesis
glgB	glycogen biosynthesis
glgC	glycogen biosynthesis
glgD	glycogen biosynthesis
glgP	glycogen biosynthesis
glnH	glutamine uptake
glnM	glutamine uptake
glnP	glutamine uptake
glnQ	glutamine uptake
hbuT	3-hydroxybutyrate utilization
htrC	unknown
ispG	MEP pathway of isoprenoid biosynthesis
kamA	unknown
katX	detoxification (degradation) of hydrogen peroxide
ligD	non-homologous end joining DNA repair, repair of gapped DNA substrates
lonB	protein quality control
lysA	biosynthesis of lysine
lytH	endospore cortex maturation
mbl	[SW\|cell shape] determination
mcsA	control of [protein\|908DB17A39D518E84977250C55825E77FA02E391\|CtsR] activity
mcsB	control of [protein\|908DB17A39D518E84977250C55825E77FA02E391\|CtsR] activity
mmgA	mother cell metabolism, leucine utilization
mmgB	mother cell metabolism
mmgC	mother cell metabolism
mmgD	mother cell metabolism
mmgE	mother cell metabolism
mmgF	mother cell metabolism
murB	peptidoglycan precursor biosynthesis
murG	peptidoglycan precursor biosynthesis
pbpF	bifunctional glucosyltransferase/ transpeptidase, synthesis of spore peptidoglycan
pbpG	bifunctional glucosyltransferase/ transpeptidase, synthesis of spore peptidoglycan
pbpI	unknown
pdaA	spore cortex peptidoglycan synthesis
pdaB	spore cortex formation
pghL	polyglutamic acid degradation
phoB	aquisition of phosphate upon phosphate starvation, ether lipid synthesis
phoP	regulation of phosphate metabolism ([gene\|E0430C16C41440633647976A0F9183E24268E198\|phoA], [gene\|3B95AB3021280215B6B487A348D78FB5797AEEA6\|phoB], [gene\|597771E2E8EC31ED9B2CC8C0E4D888DEEA80F689\|phoD], [gene\|F7D869F77E2275110737EF658C58FA1BF742D73F\|resABCDE], [gene\|72A89412C53703F96F835D26307263F5D1A4AB4E\|tagA]-[gene\|911A4D957A6C0DFC636A152395119DBFC777DDA2\|tagB], [gene\|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C\|tagDEF], [[gene\|tuaA\|tuaA-H]])
phoR	regulation of phosphate metabolism
prkA	control of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK]-dependent gene expression
refZ	relocalization of the [protein\|search\|FtsZ ]ring, placement of the sporulation septum
rppH	DNA repair, RNA degradation
rsfA	control of expression of [protein\|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA\|SigF]-dependent genes
sbp	unknown
scoA	3-hydroxybutyrate utilization
scoB	3-hydroxybutyrate utilization
seaA	involved in spore envelope assembly
sigF	transcription of [SW\|sporulation] genes (early forespore)
sigG	transcription of [SW\|sporulation] genes (late forespore)
sigK	late mother cell-specific gene expression
sigKC	late mother cell-specific gene expression
sodF	detoxification of oxygen radicals
splA	regulation of the splA-splB operon
splB	protection of spore DNA against photodamage
spmA	germination
spmB	germination
spoIIAA	control of [protein\|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA\|SigF] activity
spoIIAB	control of [protein\|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA\|SigF] activity; phosphorylation and inactivation of [protein\|3936E91C062074BFE4284B54A8CC33F35F94F5EE\|SpoIIAA]
spoIID	dissolution of the septal cell wall
spoIIIAA	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAB	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAC	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAD	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAE	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAF	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAG	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]
spoIIIAH	activation of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG], forespore encasement by the spore coat
spoIIID	regulation of mother cell gene expression
spoIIM	dissolution of the septal cell wall
spoIIP
spoIIQ	forespore encasement by the spore coat
spoIIR	control of [protein\|search\|SigE ]activation
spoIISA	programmed cell death
spoIVB	control of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK] activation
spoIVCA	excision of the skin element, creation of the sigK gene
spoIVFA	control of [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK] activation
spoIVFB	processing of pro-sigma-K to active [protein\|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4\|SigK]
spoVAA	spore maturation
spoVAB	spore maturation
spoVAC	spore maturation
spoVAF	spore maturation
spoVB	spore cortex peptidoglycan synthesis
spoVD	synthesis of spore peptidoglycan
spoVE	spore cortex peptidoglycan synthesis
spoVFA	dipicolic acid production
spoVFB	dipicolic acid production
spoVIF	required for spore coat assembly and resistance
spoVK	spore maturation
spoVR	spore cortex synthesis
spoVT	regulation of forespore gene expression
spoVV	transport of dipicolinic acid across the outer forespore membrane
sprB	excision of [SW\|SP-beta prophage]
spsA	spore crust polysaccharide synthesis
spsC	legionaminic acid synthesis
spsD	legionaminic acid synthesis
spsE	legionaminic acid synthesis
spsF	spore crust polysaccharide synthesis
spsG	legionaminic acid synthesis
spsI	rhamnose biosynthesis, spore crust polysaccharide synthesis
spsJ	rhamnose biosynthesis, spore crust polysaccharide synthesis
spsK	rhamnose biosynthesis, spore crust polysaccharide synthesis
spsL	rhamnose biosynthesis, spore crust polysaccharide synthesis
sqhC	biosynthesis of sporulenes
sscA	spore coat assembly
stoA	spore cortex formation, maturation of [protein\|search\|SpoVD ]in the forespore outer membrane
tlp	unknown
tuaF	biosynthesis of teichuronic acid
tuaG	biosynthesis of teichuronic acid
tuaH	biosynthesis of teichuronic acid
usd	required for translation of [protein\|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397\|SpoIIID]
uxaA	hexuronate utilization
uxaB	hexuronate utilization
uxuA	hexuronate utilization
yabP	[SW\|sporulation]
yabQ	sporulation
yabR	unknown
yabT	control of DNA integrity during spore development
ybaK	unknown
ybxH	unknown
ycgF	unknown
ycgG	unknown
yckC	unknown
yckD	unknown
ydcA	unknown
ydcC	unknown
ydfR	unknown
ydfS	unknown
ydgA	unknown
ydgB	unknown
ydhF	unknown
ydjP	unknown
yeaA	unknown
yesJ	unknown
yesK	unknown
yfhD	survival of ethanol stress and low temperatures
yfhE	survival of stress conditions and low temperatures
yfhS	unknown
yfkD	unknown
yfnD	unknown
yfnE	unknown
yfnF	unknown
yfnG	unknown
yfnH	unknown
yhaL	[category\|SW 4.2\|Sporulation]
yhbH	[category\|SW 4.2\|Sporulation]
yhcM	unknown
yhcO	unknown
yhcQ	unknown
yhcV	unknown
yhfM	unknown
yhfW	unknown
yhxC	unknown
yisZ	sulfate reduction and activation
yitA	sulfate reduction and activation
yitB	sulfate reduction and activation
yitC	unknown
yitD	biosynthesis of L-sulfolactate
yitF	unknown
yitG	unknown
yjaV	[category\|SW 4.2\|Sporulation]
yjbA	unknown
yjcA	unknown
yjfA	unknown
yjmC	unknown
yjmD	utilization of dulcitol
yjmF	unknown
ykoV	non-homologous end joining DNA repair, repair of gapped DNA substrates
ykvI	unknown
ykvQ	unknown
ylbB	unknown
ylbC	unknown
ylbE	unknown
ylmC	unknown
yloB	accumulation of calcium in the spore
ylxW	unknown
ylxX	unknown
ylyA	control of [protein\|5F24258282F3166B7696B9E9ABC1706E4D06C944\|SigG]-dependent [SW\|transcription]
ymxH	unknown
yndA	unknown
yngE	mother cell metabolism, leucine utilization
yngF	mother cell metabolism, leucine utilization
yngG	mother cell metabolism, leucine utilization
yngH	mother cell metabolism, leucine utilization
yngHB	mother cell metabolism, leucine utilization
yngI	mother cell metabolism, leucine utilization
yngJ	mother cell metabolism, leucine utilization
yoaR	unknown
yoaW	unknown
yobW	unknown
yocL	unknown
yodH	unknown
yodP	unknown
yodQ	unknown
yodR	unknown
yodS	unknown
yodT	unknown
yokU	unknown
yozQ	unknown
ypfB	unknown
yphA	unknown
ypjB	unknown
ypqA	unknown
ypzA	unknown
ypzF	unknown
yqcK	unknown
yqfC	unknown
yqfD	sporulation
yqfQ	unknown
yqfX	unknown
yqfZ	unknown
yqhG	unknown
yqhH	unknown
yqhP	unknown
yqhQ	survival of stress conditions
yqjC	unknown
yqxA	unknown
yqzG	unknown
yrkC	unknown
yrrD	unknown
yrrS	unknown
ytcB	unknown
ytcC	lipopolysaccharide biosynthesis
yteA	unknown
yteV	unknown
ytfI	unknown
ytlA	unknown
ytlC	unknown
ytlD	unknown
ytrH	unknown
ytrI	spore cortex formation
ytvI	unknown
ytxC	unknown
yuiC	unknown
yurS	unknown
yusN	unknown
yuzA	unknown
yveA	unknown
ywcA	unknown
ywcB	unknown
ywjD	protection of developing and dormant spores against UV DNA damage
ywjE	phospholipid biosynthesis
ywnJ	unknown
ywrJ	unknown
yxeD	unknown
yxjF	3-hydroxybutyrate utilization
yyaC	unknown
yyaD	unknown

4.2.1.5. Newly identified sporulation proteins (based on transcription profiling)

Name	Function
bpsA	polyketide synthesis
bpsB	polyketide synthesis
citH	citrate uptake
comER	control of biofilm formation and sporulation via the phosphorelay
cypA	unknown
fadM	fatty acid degradation
lplD	utilization of pectin
mciZ	inhibits GTPase activity of [protein\|41872E2EF00C79918DD077F2EF78F37E24FEB110\|FtsZ] and Z ring formation during sporulation
mstX	unknown
nrnB	degradation of RNA oligonucleotides
yaaC	unknown
yabS	unknown
ybbC	unknown
ybeF	unknown
ybfJ	unknown
ycgH	unknown
ycgI	unknown
ycgL	unknown
yclG	unknown
ydzH	unknown
ydzR	unknown
yetF	unknown
yetO	fatty acid metabolism
yezF	unknown
yflJ	unknown
yflN	unknown
yfmA	unknown
ygzA	unknown
ygzC	unknown
yhcT	RNA modification
yhdB	unknown
yhdC	unknown
yheF	unknown
yhfA	unknown
yhfN	unknown
yhjQ	prevention of copper toxicity
yhzF	unknown
yisN	unknown
yitE	unknown
yitQ	resistance to [protein\|330CB6A25181F7AFD3C63F73CA21A3428882D100\|YitM]
yizC	unknown
yizD	unknown
yjaU	unknown
yjaZ	unknown
yjbE	unknown
yjcZ	unknown
yjnA	unknown
yjzC	unknown
yjzK	unknown
ykjA	unknown
ykoN	unknown
ykoP	unknown
ykoQ	unknown
ykoS	unknown
ykoT	unknown
ykoY	resistance to Mn²⁺ intoxication
ykpC	unknown
ykuS	unknown
ykwB	unknown
ykzD	unknown
ykzE	unknown
ykzH	unknown
ykzP	unknown
ykzV	unknown
ylaK	unknown
ylaM	glutamine degradation
ymaF	unknown
ymfD	iron acquisition
ymfJ	unknown
yncE	unknown
yndM	unknown
ynfE	unknown
yngK	unknown
yngL	unknown
ynzE	unknown
ynzL	unknown
yoaI	unknown
yoaM	unknown
yoaQ	unknown
yoaU	unknown
yocN	unknown
yodL	control of [SW\|cell division]
yodN	unknown
yodU	legionaminic acid synthesis
yojB	unknown
yoyB	unknown
yoyE	unknown
yoyF	unknown
yoyG	unknown
yozD	unknown
yozE	unknown
yozF	unknown
yozN	unknown
yozT	unknown
ypeQ	unknown
yppC	unknown
yppD	unknown
ypqP	legionaminic acid synthesis
yptA	unknown
ypzC	unknown
ypzD	unknown
ypzG	unknown
ypzH	unknown
ypzI	unknown
yqaN	unknown
yqaO	unknown
yqcI	unknown
yqeC	unknown
yqgE	unknown
yqgO	unknown
yqhO	unknown
yqhR	unknown
yqhV	unknown
yqjB	unknown
yqzO	unknown
yrbD	uptake of alanine
yrbG	unknown
yrrI	may control [SW\|cell wall synthesis ]by the [SW\|penicillin-binding proteins]
yrzA	unknown
yrzE	unknown
yrzK	unknown
yrzN	unknown
yrzQ	unknown
yrzR	unknown
ytcA	unknown
ytdA	unknown
yteT	unknown
ythA	respiration
ythB	respiration
ytkC	unknown
ytvB	unknown
ytwI	unknown
ytzC	unknown
ytzH	unknown
ytzL	unknown
yubC	unknown
yueG	unknown
yufS	unknown
yugF	unknown
yugO	potassium exporter
yugP	unknown
yugS	unknown
yugT	unknown
yumB	unknown
yunC	unknown
yurZ	unknown
yusW	unknown
yutC	unknown
yutG	unknown
yuzE	unknown
yuzF	unknown
yuzI	unknown
yuzL	unknown
yuzM	unknown
yvaC	unknown
yvaM	unknown
yvnB	unknown
ywaF	unknown
ywbA	unknown
ywbB	unknown
ywkF	unknown
ywmA	unknown
ywnG	unknown
ywoC	unknown
ywoD	unknown
ywqI	unknown
ywqJ	unknown
ywqK	unknown
ywqL	DNA repair
ywrK	unknown
yyaL	unknown
yybP	unknown
yycE	unknown
yycN	unknown
yycO	unknown
yycP	unknown
yycQ	unknown
yyzB	unknown

important reviews

22091839,20833318,16045607,15819616,15659154,15556029,15187183,15035041,2257467,22882546,24983526,25646759,30855188,32660383

important original publications

21667307,21665972,21905219,23284278,25341802,25356555,25548246,26735940,29425492


4.2.1	Sporulation proteins
4.2.2	phosphorelay
4.2.3	Sporulation/ other
4.2.4	Germination
4.2.5	Germination/ based on similarity